Internet of Things (IoT) is one of the emerging technologies in the world and it changes the life style of the people. Nowadays, there is a drastic increase of sensor enabled physical devices connected in the internet and at the same time, quick responsiveness is very important for transferring the data from source to destination. Hence, routing plays a crucial role in IoT. In IoT routing protocol, the requirement is dynamically varying depends on the on the application. The mobility based IoT application like healthcare, smart school, animal tracking and etc. The term mobility denotes entire node can move dynamically from one place to another place within the coverage area of the network. In this paper, we introduce the Mobility and Energy aware routing protocol (ME-RPL), which consider the metrics received signal strength (RSSI), expected transmission count (ETX), battery depletion index (BDI). The DODAG root node sends the DODAG Information Object (DIO) control messages to the entire participant node in LLN. If the participant node is within the coverage of existing DODAG, then it can choose the preferred parent based on the routing metric. The simulation has done using COOJA simulator in different IoT mobility scenario. The proposed work (ME-RPL) provides the better result in terms of packet delivery ratio and network lifetime, than other similar protocol RPL, mRPL, D-RPL. © RJPT All right reserved.