Rapidly changing global business environment makes the supply chain to face numerous challenges and sets rigorous target requirements for continuing the operations. To sustain in this unpredictable environment firm needs strategy on supply chain flexibility (SCF). We intend to empirically examine the impact of supply chain flexibility on supply chain performance (SCP) and also to identify the antecedent variables to SCF. This study includes 249 samples from manufacturing industry. We used structural equation model with a partial least square (PLS-SEM) approach for examining the model and SmartPLS 2.0 software was used for analysis. The result indicates that the SCF significantly contributes to the supply chain performance namely demand management, supply chain reliability (SCR) and supply chain knowledge development. The mediation analysis shows that SCF partially mediates the relationships between supply chain capabilities and supply chain performance. The findings contribute to the existing literature and also provide direction for further research in SCF. Copyright © 2020 Inderscience Enterprises Ltd.