A multi-objective integrated scheduling of machines and material handling equipment in an automated manufacturing system is addressed in this paper. The FMS environment is modeled with the incorporation of six multioperational machines and two automated guided vehicles (AGVs). An ant colony optimization (ACO) is proposed to optimize a multi-objective function that maximize machine utilization, maximize profit made, minimize AGV traveling time, and minimize AGV energy utilization concurrently. The performance of the proposed ACO algorithm is compared with conventional priority dispatching rules (pdrs) and it is found that proposed ACO performs better over the pdrs considered. © 2009 IEEE.