The multi-scale method which is being used is generally used for solving coupled equations, and this method is widely used for reservoir simulation. The coupling factors which needs to be solved are the pressure equation and the transport equation .Both the equations are going to be solved as a decoupled system, while the pressure equation will be solved in a coarser grid and the transport equation will be solved in a finer grid. There are several multi-scale methods which can be used for reservoir simulation, but the multi-scale mixed finite element (MsMFE) method is the one which grabs all the sub grid topographical diverseness into the coarse scale using mathematical basis functions. A global formulation can be used to couple the important multi-scale information which will be grabbed by the basis functions thereby providing good resemblance to the solution for the subsurface flow.According to the literature the most commonly used formulation which is being used for the multi-scale mixed finite element method (MsMFE) for incompressible two phase flow mainly deals with common flow physics. In this paper, the formulation which is being used takes into considerations the gravity, compressibility, spatially dependent capillary and relative permeability effects. Our main aim is to find out the efficiency of this formulation and the Multi-scale mixed finite element method (MsMFE) by comparing our results with the results obtained from two different reservoirs in India. We have used MRST (MATLAB Reservoir Simulation Toolbox) for the simulation of the reservoir. Our results will include pressure distribution, Flux distribution and the saturation fields throughout the reservoir. © 2019, Pet Coal.