The space division multiple access-orthogonal frequency division multiplexing (SDMA-OFDM) wireless system has become very popular owing high spectral efficiency and high load capability. The optimal maximum likelihood multiuser detection (MUD) technique suffers from high computational complexity. On the other hand the linear minimum mean square error (MMSE) MUD techniques yields poor performance and also fails to detect users in overload scenario, where the number of users are more than that of number of receiving antennas. By contrast, the differential evolution algorithm (DEA) aided minimum symbol error rate (MSER) MUD can sustain in overload scenario as it can directly minimizes probability of error rather than mean square error. However, all these classical techniques are still complex as these do channel estimation and multiuser detection sequentially. In this paper, complex multi layer perceptron (CMLP) neural network model is suggested for MUD in SDMA-OFDM system as it do both channel approximation and MUD simultaneously. Simulation results prove that the CMLP aided MUD performs better than the MMSE and MSER techniques in terms of enhanced bit error rate performance with low computational complexity. © 2013 Springer Science+Business Media New York.