Nanomedicine is a new field of medicinal science in which nanotechnology has found its way into medicine. Nanoantibiotics should be the main focus due to the growing amount of ‘superbugs’ or multi-drug resistant bacteria as one of the major clinical problems all around the globe. Biological production of nanoparticles has found its greatest application towards medicine and mainly in drug delivery systems. These highly-targeted nanoparticles that can be able to deliver higher doses of available antibiotics could possibly overcome the problem of drug-resistant bacteria in near future. Nanoantibiotics could improve the scheme of dosage based targeted therapy as well as combination studies are being done between nanoparticles and antibiotics. This non-traditional method also provides a very less opportunity for pathogens to develop resistance because of availability of different groups and different targets of nanoparticles. This review focuses on nanoparticles that can potentially be used to tackle this problem of drug resistant bacteria. © 2017 Bentham Science Publishers.