Cellulose is abundant in the nature and nanocellulose (NC) in particular is regarded as a credible green substrate to be used in bio nanocomposites for various applications. NC exhibits excellent mechanical reinforcement properties comparable to conventionally used materials due to its high specific surface area and tunable surface chemistry. Additionally, low toxicity, biodegradability and biocompatibility of NC deem it a promising material for use in different biomedical applications. In this review, we highlight the biomedical applications of NC based hydrogels and aerogels/nanocomposites and advancements of their employment in the areas of wound dressing, drug delivery, tissue engineering, scaffolds and biomedical implants. This review also explores the recent use of NC in making biosensors for the detection of cholesterol, various enzymes and diseases, heavy metal ions in human sweat and urine, and for general health monitoring. © 2020 Elsevier B.V.