A better formulation ensures a better delivery system. This study is based on this fact, having a greater belief in a natural product compared to chemical counterpart. Stress is a negative concept that affects the mental and physical well being. Stress is nowadays very common in the sedentary lifestyle. Drugs that are found in the market are chemically synthesized and might cause side effects. Owing to this reason, various studies have been made to discover natural products with anxiolytic properties, amongst which the phytochemicals, is a wide area of research. An effort was made to encapsulate the phytochemical Withaferin-A, using nanoparticles. Nanoencapsulation of this phytochemical is expected to have increased bioavailability and increased water solubility. Withaferin-A was nanoencapsulated using the polymer Poly-(Lactic Acid) by solvent evaporation method, the formation of nanoparticles were found using the Atomic Force Microscopy and the concentration of loaded particles were found using the diphenyl picrylhydrazyl assay. © IDOSI Publications, 2013.