Danie Kingsley J

Department of Integrative Biology

School of Bio Sciences and Technology

Vellore Campus

Ranjan S

Dasgupta N

Saha P.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

&nbsp;

&nbsp;

VIT University

Journal of Pharmacy Research

Environmental Chemistry Letters

Toxicity and regulations of food nanomaterials

Nanoencapsulation is a promising technology allowing miniaturized dosage and administration of valuable volatiles, degradable bioactives and biologicals. The produced nanoparticles display qualities such as a sustained availability of active constituents, targeted delivery and enhanced shelf stability. This review presents methods of nanoencapsulation and nanoemulsion, such as solvent evaporation–emulsification, coacervation, nanoprecipitation, inclusion complexation, electrospraying, electrospinning, freeze drying and spray drying. Those methods are particularly relevant for the pharmaceutical, food and agricultural industries. © 2019, Springer Nature Switzerland AG.

Methods for nanoemulsion and nanoencapsulation of food bioactives

Nanotechnology has seen exponential growth in last decade due to its unique physicochemical properties; however, the risk associated with this emerging technology has withdrawn ample attention in the past decade. Nanotoxicity is majorly contributed to the small size and large surface area of nanomaterials, which allow easy dispersion and invasion of anatomical barriers in human body. Unique physio-chemical properties of nanoparticles make the investigation of their toxic consequences intricate and challenging. This makes it important to have an in-depth knowledge of different mechanisms involved in nanomaterials's action and toxicity. Nano-toxicity has various effects on human health and diseases as they can easily enter into the humans via different routes, mainly respiratory, dermal, and gastrointestinal routes. This also limits the use of nanomaterials as therapeutic and diagnostic tools. This review focuses on the nanomaterial-cell interactions leading to toxicological responses. Different mechanisms involved in nanoparticle-mediated toxicity with the main focus on oxidative stress, genotoxic, and carcinogenic potential has also been discussed. Different methods and techniques used for the characterization of nanomaterials in food and other biological matrices have also been discussed in detail. Nano-toxicity on different organs-with the major focus on the cardiac and respiratory system-have been discussed. Conclusively, the risk management of nanotoxicity is also summarized. This review provides a better understanding of the current scenario of the nanotoxicology, disease progression due to nanomaterials, and their use in the food industry and medical therapeutics. Briefly, the required rules, regulations, and the need of policy makers has been discussed critically.

Critical Reviews in Food Science and Nutrition

Nanomaterials in food and agriculture: An overview on their safety concerns and regulatory issues

Titanium dioxide nanoparticles are widely used in consumer products, paints and pharmaceutical preparations. They have been shown to induce cytotoxicity, genotoxicity and carcinogenicity—in vitro and in vivo. So far there is lack of standardized protocol for in silico analysis of nano-toxicological evaluations. In the present study, it was attempted to analyze the titanium dioxide nanoparticles-protein interaction through docking using AutoDock 4.0.5 software. Titanium dioxide nanoparticles with particle size of 1.09 nm were docked with different cellular proteins. Binding site area and volume has been determined by using CastP online server and docking has been performed at the active site as a pocket. The docked structures were analyzed for the most efficient binding with amino acids. It is the first study to report the interaction of titanium dioxide nanoparticles without any surface modification with proteins using docking analysis. The negative binding and docking energy inferred that the interaction of titanium dioxide nanoparticles with certain proteins is significant. Titanium dioxide nanoparticle shows significant interaction with intercellular adhesion molecule-1, P38 mitogen-activated protein kinases (P-38), placental growth factor and nuclear factor kappa-light-chain-enhancer of activated B cell proteins. Further, it has been observed that titanium dioxide nanoparticles show frequent interaction with proline, lysine as well as leusine. © 2015, The National Academy of Sciences, India.

Proceedings of the National Academy of Sciences, India Section B: Biological Sciences

A Novel Approach to Evaluate Titanium Dioxide Nanoparticle–Protein Interaction Through Docking: An Insight into Mechanism of Action

Due to their small size and unique physico-chemical characteristics, nanomaterials have gained importance in the agri-food sector, notably in preservation and packaging. Future applications will focus on shelf life, food quality, safety, fortification and biosensors for contaminated or spoiled food, irrigating water and drinking water. Different types and shapes of nanomaterials are being used depending upon the needs and nature of the work in agriculture and water quality management. Here we review the application of nanotechnology in agriculture. The major points discussed are: (1) Nanomaterials for agriculture and water quality management. (2) Research interests such as nanoscale carriers, fabricated xylem vessels, nanolignocellulosic materials, clay nanotubes, photocatalysis, bioremediation of resistant pesticides, disinfectants, agricultural wastewater treatment, nanobarcode technology, quantum dots for staining bacteria and nanobiosensors. (3) Nanotechnological applications for agriculture, which includes nanolignodynamic metallic particles, photocatalysis, desalination, removal of heavy metals and wireless nanosensors. © 2017, Springer International Publishing AG.

Applications of nanotechnology in agriculture and water quality management

Journal of Controlled Release

“Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold” [J. Control. Release 117 (2006) 380–386]

Biomaterials

The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages

Biomedical Microdevices

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

Journal	Data powered by TypesetJournal of Pharmacy Research
Publisher	Data powered by TypesetElsevier BV
ISSN	0974-6943
Open Access	0