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A new naphthalimide-based fluorescent probe [(S)-1 and (S)-2] employing (S)-BINOL unit as a chiral responsive group has been designed and synthesized. Ligand (S)-1 showed greater fluorescence enhancement towards (R)-amino alcohol and the value of enantiomeric fluorescence difference (ef) ratio reached as high as 7.07 for phenylalaninol while (S)-phenylalaninol did not show much enhancement in fluorescence, whereas ligand (S)-2 showed ef value of 4.49 for phenylalaninol. The fluorescence enhancement can be attributed to imine formation and H-bonding. Further, the R/S chiral selectivity of ligands (S)-1 and (S)-2 is opposite. The chiral discrimination ability of (S)-1 and (S)-2 was tested via fluorescence, NMR and CD spectral analysis. The results indicated that the sensor (S)-1 was very promising for use as a fluorescent sensor in determining the enantiomeric composition of α-amino alcohols. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Journal | Data powered by TypesetChemistrySelect |
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Publisher | Data powered by TypesetWiley |
ISSN | 2365-6549 |
Open Access | 0 |