This manuscript is mainly focusing on the approximate controllability of Hilfer fractional neutral stochastic integro-differential equation with infinite delay. We study our primary outcomes by utilizing the theoretical concepts related to the fractional calculus and Krasnoselskii's fixed point theorem. First, we prove the approximate controllability of the fractional evolution system. Then, we extend our results to the concept of nonlocal conditions. Last, we provide a theoretical application to assist in the effectiveness of the discussion. © 2020 Wiley Periodicals LLC