Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. “Next generation delivery systems” may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.

George Priya Doss C

Department of Integrative Biology

School of Bio Sciences and Technology

Vellore Campus

Sharma A.R

Kundu S.K

Nam J.-S

Sharma G

Lee S.-S

Chakraborty C.

Fulltext

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?

BioMed Research International

Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route is offering great promises for gene therapy. This review is an attempt to depict a portrait about the polymer based liposomal gene delivery systems and their future applications. Herein, we have discussed in detail the characteristics of liposome, importance of polymer for liposome formulation, gene delivery, and future direction of liposome based gene delivery as a whole.

Recent Trends of Polymer Mediated Liposomal Gene Delivery System

Over the past decades, therapeutic use of many protein and peptides are hampered by in vitro and in vivo stability, short-half life and immunogenicity. To address an unmet need of protein therapeutics, biologists and chemists together have invented polymerprotein conjugates. These polymer-protein therapeutics have successfully developed and investigated extensively with a variety of natural and synthetic biodegradable polymers such as poly (ethylene glycol), polysialic acid, polyglycerol, polyamidoamine, poly (methyl methacrylate), poly(hydroxyethyl methacrylate), poly(N-isopropylacrylamide), poly(ethylene glycol) methyl ether acrylate, poly(N-vinylpyrrolidone), dextran, dextrin, hyaluronic acid and hydroxylethyl starch. Polymer-protein therapeutics has attracted tremendous attention in the last few years. Such strategies have the potential to develop as next generation protein therapeutics. This chapter will highlight synthesis strategies, design concepts, recent progress, clinical studies and future prospects for protein-and peptide-polymer conjugates. © 2017 Scrivener Publishing LLC.

Handbook of Composites from Renewable Materials

Biodegradable polymers for protein and peptide therapeutics: Next generation delivery systems

Pharmaceuticals in conjunction with nanoparticle delivery systems are growing towards new heights. The aim of this review is to gain a thorough understanding of different types and characteristics of nanoparticle based delivery systems, important properties of delivery systems, pharmaceutical ingredient loading and release in the nanoparticle delivery systems. In this review, we have also highlighted about the promising pharmaceutical deliveries like brain targeted delivery, ocular delivery, oral delivery, dermal and transdermal delivery, cancer chemotherapy, vaccine delivery, nucleic acids delivery and delivery system coupling to implants. A snapshot of the nanoparticle mediated drug deliveries which are commercially available and ongoing clinical trials have been provided.

Frontiers in Bioscience

Nanoparticles as smart pharmaceutical delivery

European Journal of Medicinal Chemistry

Amphiphilic Cationic Carbosilane–PEG Dendrimers: Synthesis and Applications in Gene Therapy

Benzothiazole head group based cationic lipids: Synthesis and application for gene delivery

Pharmaceutical Research

The Immunogenicity of Polyethylene Glycol: Facts and Fiction

International Journal of Pharmaceutics

Inhaled proteins: Challenges and perspectives

Journal	BioMed Research International
Publisher	Hindawi Limited
ISSN	2314-6133
Open Access	Yes