The study has been carried out in the medium Select hospitals at Tamil Nadu, India. The purpose of this study is to determine the attitude of nurses towards computerization and factors affecting the use of computers. Variables including gender, marital status, qualification, age and type of job have been studied. A random sample of 600 nurses formed the study population. Out of them 164 nurses responded to the survey. Analysis of Variance (ANOVA) test was done to analyze the data. Results show that gender has no impact on nurse’s attitude towards computerization. Marital status, qualification level, age and type of job have been found to affect the attitude of nurses in use of computers at their workplace. Unmarried nurses have more positive attitude than married nurse. Nurses possess bachelor degree got more positive attitude than diploma holder nurses towards computers. Nurses with age range 20-25 years had more positive attitude than nurses above 26 years. Full time working nurses have more positive attitude than part time working nurses towards computerization. Lack of computers is the major concern in use of computers at their work place. Results of the study may be useful for nurse administrators and educators to develop and design educational and training programs. © 2016, Research Journal of Pharmacy and Technology. All rights reserved.