Purpose: The main aim of the study is to identify the dimensions and factors influencing the occupational stress of nurses' who are employees in a private hospital at Vellore, Tamil Nadu. Methodology: A questionnaire was used to measure the professional stress among the nurses in the hospital. The sample of the research consists of 62 nurses working in a private hospital at Vellore, Tamil Nadu. The questionnaire contains two segments. The first portion deals with socio-demographic information and second segment consist of six dimension say death and dying(6 variables), conflict with physicians (4 variables), lack of support (3 variables), conflict with other nurses (4 variables), work load (4 variables) and uncertainty concerning treatment (4 variables). Distress Implications: Majority of the nurses expressed their frustration about the conflict with their supervisors, inadequate manpower to cover the unitsand also complaint about the inadequate information provided by the physicians with regard to the treatment of the patients. The hospital management should employ adequate staff members for the smooth functioning of the work in each unit. They should also arrange meeting between physician and nurses as well as between nurses and supervisors wherein they discuss about all the issues in an amicable manner. Hence, this research paper report about the dimension influencing the occupational stress of nurses. The researchers confirmed from this study that the socio demographic factors of the nurses play a key role with regard to occupational stress. © 2017 Serials Publications Pvt. Ltd.