Tissue inhomogeneity diagnosis using optics is fast advancing technique in the field engineering in developing optical medical electronics. Tissues can be either less transparent such as skin, tissues present in brain and blood vessel walls or high transparent such as tissues present in eye i.e., cornea, lens. In the present work the less transparent tissues phantoms are taken for the simulation in detection of the inhomogeneous tissues. The propagation of light through tissue is made up of two components: transmittance through the tissue and backscattered light by the deep and shallow tissues. This backscattered light is made up of details regarding intra-cutaneous patterns, tissue inhomogeneity and other erythema multiforme. A lightweight hand-held optical device that includes an array of light source and photo-diode is used for the detection purpose. The light source illuminates the examination portion and the photo-diodes that are placed at certain equal distance picks the backscattered light. This value is converted to voltage of appropriate level and then computerized for further proceeding. The current approach based on the fact that the light reflected by regular and irregular tissue is different, and this is due to the varying optical properties of tissue. The indicated difference is very definite and specific that it can be adopted to detect and locate the abnormal tissues in the skin on superficial layers. © Research India Publications.