In recent years, fatigue is a prominent failure mechanism for any vehicle's frame Structure, and it can lead to serious accidents, costly recalls, and poor product image for the vehicle's frame manufacturers. This paper deals with investigation of the fatigue behaviour of the vehicle's chassis and has carried out a design and optimization in Solid Works. In the first part of the study, the static loads acting on the connecting rod, after that the work is carried out for safe design. Based on the observations of the static Finite Element Analysis (FEA) and the load analysis results, the load for the optimization study was selected. The results were also used to determine degree of stress, and the fatigue model to be used for analysing the fatigue strength. Outputs include fatigue life, damage, factor of safety, fatigue sensitivity. A method has been proposed to optimize the wheels and frame's material and design for an improved fatigue resistance. © 2016, SPB Pharma Society. All rights reserved.