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Particle Size Reduction of Ramipril Using Cinnamon Oil Based Microemulsion System and Acute Toxicity of the Vehicle in Female Wistar Rats
Nirmala M.J, Ebenazer A, , ,
Published in American Scientific Publishers
Volume: 8
Issue: 1
Pages: 66 - 73
Microemulsions as drug delivery vehicles have gained fame for their capability of solubilizing aqueous insoluble drugs with poor bioavailability. Ramipril, one of its kind, was chosen to improve its physico-chemical properties by incorporating in cinnamon oil based microemulsion system. This enabled enhanced solubilization and particle size reduction with mean droplet diameter in the range of 7.2 nm with minimum polydispersity index. The comparison made between the drug-loaded formulation and its blank counterparts demonstrated similarity in the visual appearances, turbidity and viscosity measurements; and very slight increase regarding the pH and conductivity measurements. Owing to the best performance of the drug delivery vehicle, acute toxicity was performed on female Wistar rats. The rats observed no signs of mortality or toxicity at the end of 21 days when a highest volume (1 ml/100 gm body weight) of the vehicle was given orally. Haematological parameters were also observed normal as compared to control rats. The vehicle would place a possible outcome in futuristic work. Copyright © 2014 American Scientific Publishers All rights reserved.
About the journal
JournalData powered by TypesetJournal of Bionanoscience
PublisherData powered by TypesetAmerican Scientific Publishers
Open Access0
Authors (3)