During the last few decades, there has been a considerable growth of interest in pattern recognition in the field of robotics. An application of pattern recognition in robotics includes mobile robots and service robots. Visual and signal recognition of patterns enables the robots to perform a variety of tasks such as object and target recognition, navigation, grasping, and manipulation, assisting physically challenged people. This chapter surveys trends in robotics with pattern recognition that focuses more on the interaction between robot assistive device and human with signal pattern recognition. This interaction helps to enhance the capability of people in rehabilitation and in the field of medicine. Finally, this chapter includes the application of pattern recognition in the development of a prosthetic hand.