In the case of medical applications, the main requirement is to improve the control overhead and to achieve the reliable data transmission. A ZigBee based mobile patient monitoring network model is proposed, and its performance improvement is analysed based on reduced delay and enhanced throughput. We are focusing on the separate and comparative performance evaluation of AODV and DSR routing protocol in a wireless body area network (WBAN). WBAN has numbered of the sensor nodes for collecting the physiological status of patients like ECG, temperature, Heartbeat, etc. Mobile sensor nodes forming an unpredictable topology and link instability that make routing protocols a core issue. In this paper, we considered one wireless network having the hospital care center who monitors mobile patient under AODV and DSR routing protocols, and transmits data to various nodes. Simulation has been performed using OPNET simulation tool, and the results demonstrate that the AODV routing protocol is best suited for medical monitoring system. © 2014 IEEE.