The present study aims at the experimental and numerical investigations of the Paraffin wax-based mini-channels for the performance enhancement of seven high heat-generating IC chips under the natural convection heat transfer mode. Two mini-channels (left and right) are fabricated at the periphery of the substrate board and are filled with the Paraffin wax. The IC chips are placed adjacent to these channels and supplied with non-uniform heat inputs leading to the constant volumetric heat generation in the ranges of 0.4 × 107–1 × 107 W/m3. The numerical analysis is carried out to support the experiments and it is seen that both the results match well with each other within the IC chip temperature variation of 4–5 °C. The temperature of the IC chips is reduced by 37.34–45.79% using the Paraffin wax and thus enhances their performance by 2.33–4.63 times. This confirms the significance of Paraffin wax for the cooling of the IC chips and ultimately enhances the system performance and reliability. © 2021 Elsevier Masson SAS