It is acceptable that construction industry is reaching to new bench marks by constructing certain Tall Buildings, includes of significant engineering. Construction of Tall buildings may be a complicated affair with the lateral loads playing a dominant role in design of the certain structures, where buildings need certain lateral load resisting structural system. With the evolution of technology numerous structural systems came out such as Shear Wall System, Tube in Tube, Core Out-trigger System etc. Considering the Building G+53 story's concrete Structure which is analyzed in ETABS V16.0.0 software package with different Earthquake Zones and using different Structural Systems such as Conventional System, Shear wall System, Core Out-trigger System and Wind forces exerted from IS-875-2015 (Gust Analysis), an attempt is made to compare the Performance of the three Structural Systems in all four earthquake zones Base shear, time period, top story displacement, story Drift, seismic weight of structure, and results are compared to arrive the foremost economical structure in a specific Earthquake Zone for a particular plan. © IAEME Publication.