In the present review, an attempt has been made to congregate the traditional, phytochemical and pharmacological studies done on the medicinal plant Annona squamosa, (Family annonaceae). Natural products were considered to be the best option as they have less harmful nature against the environment and other non-targeted organisms. The Annonaceous acetogenins were the expanding class of potential long chain fatty acid derivatives which were initially noticed only in the species of the family Annonaceae. Interest in these compounds reached worldwide due to their remarkable anti-tumor and other pesticidal activities. The pharmacological actions of the above plant include the regulation of hyperthyroidism and lipid-peroxidation. The plant also posses analgesic activity, anti-inflammatory activity, anti-microbial activity, cytotoxic activity, anti-oxidant activity, anti-lipidimic activity, anti-ulcer activity, molluscicidal properties, genotoxic effect, vasorelaxant activity, anti-tumour, hepatoprotective activity, larvicidal activity, insecticidal activity, anthelmintic activity, etc. The roots, leaves and seeds of Annona squamosa contain several medicinal properties. This review will be definitely helpful for the researchers as well as the clinicians dealing with Annona squamosa to know its proper usage, as the plant appears to be highly valuable due to its pharmacological / medicinal properties.