Breast cancer is one of the most common malignancies affecting women worldwide, emphasizing the need for effective therapeutic strategies. Phytochemicals derived from plants have gained significant attention due to their potential anticancer properties.

Objective

This review aims to comprehensively assess the existing literature on using phytochemical-loaded formulations as a therapeutic approach for breast cancer. By analyzing the available evidence, we aim to determine the potential benefits and limitations of these formulations in terms of their anticancer activity, bioavailability, and safety.

Methods

A systematic search of relevant databases was conducted to identify studies investigating phytochemical-loaded formulations in the context of breast cancer treatment. The inclusion criteria encompassed clinical trials, preclinical studies, and in-vitro experiments that reported using phytochemicals in various formulations for breast cancer treatment. Data extraction was performed to ensure the reliability and validity of the included studies.

Results

The review highlights the diverse range of phytochemicals used in different formulations for breast cancer treatment. Findings suggest that these formulations exhibit promising anticancer effects by targeting multiple signaling pathways in breast cancer progression, including cell proliferation, apoptosis, angiogenesis, and metastasis. Moreover, various delivery systems, such as nanoparticles, liposomes, and micelles, have enhanced phytochemicals' bioavailability and targeted delivery.