In this study we report the preparation of a composite scaffolds made from carboxymethyl cellulose (CMC) and hydroxyapatite (HA) via lyophilization technique. The morphology of the CMC/HA scaffold was observed in scanning electron microscope (SEM). The phase composition of hydroxyapatite prepared by sol-gel-microwave technique was characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). An antibiotic drug, amoxycillin, was incorporated in the composite scaffold and the release test was also performed. These results suggest that the CMC/HA scaffolds can be a promising material for bone regeneration. © 2014, Sphinx Knowledge House. All rights reserved.