Raj Kumar V

VIT Business School

Vellore Campus

Guha G

Ashok Kumar R.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

&nbsp;

&nbsp;

VIT University

Food and Chemical Toxicology

Biomedicine & Preventive Nutrition

Phenolic constituents in the polar extracts of Lawsonia inermis mitigate antimycin A-induced mitochondrial degenerative cascades in Hep3B cells

Metronidazole (MTZ), a nitroimidazole drug, is primarily used as an anti-protozoan or an anti-bacterial agent in humans, although its genotoxic and carcinogenic effects have been widely reported, particularly in aquatic organisms. MTZ may induce DNA damages through single-strand breaks, modification of bases, DNA-DNA and DNA-protein cross-links, ultimately leading to apoptosis or necrosis. Here, we have assessed the genotoxicity of MTZ in the peripheral erythrocytes of Channa punctatus, using micronucleation (MN) and binucleation (BN) as genotoxicity markers. The therapeutic potential of aqueous extract of Coriandrum sativum against MTZ-induced genotoxicity has also been examined. The results show significant (P< 0.05) increase in both MN and BN formation due to MTZ treatment. Such aberrations were higher in smaller fish samples for a particular dosage of MTZ, as established by correlation analysis between fish body weight and MN/BN count at P< 0.05. However, such degenerative damages were found to be alleviated by a great extent due to treatment with C. sativum leaf extract. Hence, we establish that MTZ can produce considerable degrees of micronucleus and binucleus formation in peripheral erythrocytes of C. punctatus, and such deleterious effect of MTZ treatment can be mitigated by aqueous extract of C. sativum leaves. © 2010 Elsevier Ltd.

Therapeutic efficacies of Coriandrum sativum aqueous extract against metronidazole-induced genotoxicity in Channa punctatus peripheral erythrocytes

International Journal of Pharmaceutical Research

Evaluation of the Safety and Efficacy of JointAid Oil in Patients with acute and chronic Musculoskeletal pain: An open label, Non-Comparative, Multicenter clinical trial

Journal of Food Science

Total Phenolic Compounds, Flavonoids, and Radical Scavenging Activity of 21 Selected Tropical Plants

World Journal of Gastroenterology

Negundoside, an irridiod glycoside from leaves of Vitex negundo , protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride

Food Chemistry

Antioxidant capacity and phenolic content of cocoa beans

Systematic evaluation of natural phenolic antioxidants from 133 Indian medicinal plants

Polyphenolic constituents of methanolic and aqueous extracts of Vitex negundo render protection to Hep3B cells against oxidative cytotoxicity

Journal	Data powered by TypesetFood and Chemical Toxicology
Publisher	Data powered by TypesetElsevier BV
ISSN	0278-6915
Open Access	0