Tea polyphenols (TPPs) comprise preventive and therapeutic potentials against cancer, cardiovascular and neurological disorders. Chemical instability of TPP which leads to low bioavailability is the major constrain to its use as therapeutic agent. The authors prepared TPP encapsulated solid lipid nanoparticles (TPP-SLNs) to increase its stability and bioefficacy. Comparison of Fourier transformed infrared spectra of unloaded SLN, free TPP and TPP-SLN indicated encapsulation of TPP. Sustained release of TPP from TP-SLN was observed. TPP-SLN showed prolonged free radical scavenging activity compared with free TPP indicating protection of TPP. TPP-SLN showed activation of Caspases-9 and -3 cascades in breast cancer cell line (Michigan cancer foundation (MCF)-7) at in vitro conditions. Biochemical parameters were altered in Ehrlich ascetic carcinoma (EAC) cell bearing mice compared with normal (uninduced) mice which were ameliorated significantly by oral feeding of TPP-SLN. Oral administration (pre- and post-treated) of TPPSLN in EAC bearing mice resulted in significant increase of plasma haemoglobin, glucose, superoxide dismutase and catalase when compared with EAC bearing control mice. Other biochemical parameters (cholesterol, bilirubin, triglyceride, urea, total protein, alanine aminotransferase, alkaline phosphatase and aspertate transaminase were significantly decreased on oral administration (pre- and post-treated) of TPP-SLN in EAC bearing mice. © 2016 The Institution of Engineering and Technology.

Abul Kalam Azad Mandal

Department of Biotechnology

School of Bio Sciences and Technology

Vellore Campus

Kulandaivelu K

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

IET Nanobiotechnology

Tea, the most consumed nonalcoholic beverage is being used worldwide as a major health drink due to some of its important constituents like polyphenols, caffeine, theanine, saponin. Among these constituents, polyphenols are most important due to their potential applications related to human health. The major constituent of tea polyphenols, responsible for several health benefits, known as catechins constitute about 30–42% of the dry weight. Some of the major health benefits of tea polyphenols include their anticancer property, antioxidant activity, antimicrobial activity, effects in cardiovascular diseases, effects in neuroprotection, and antidiabetic and psychotropic effects. In spite of several impressive data on health benefits of tea polyphenols, there are certain constraints like bioavailability, stability, and metabolic transformation under physiological conditions which limit the application of tea polyphenols as a therapeutic agent. To overcome these limitations, certain approaches like prodrug approach and the nanoencapsulation have been attempted. Of these two approaches, use of nano-based carriers could be reliable for delivery of tea polyphenols. Nanoparticles, due to their small size could penetrate through small capillaries and are taken up by the cells allowing maximum drug accumulation at the target site and allow sustained release of drug at the target site over a period of time. Different types of nanoparticles have been used for this purpose which includes lipid-based nanomaterials, dendrimers, and polymeric nanoparticles including several proteins and copolymers. Among all these materials used, polymeric nanoparticles are widely used as nano-based carriers due to some of its properties such as biodegradability, nonantigenic, metabolizable, and easily modifiable for surface alterations. With these implications, several new formulations are being developed by encapsulating tea polyphenols in polymeric nanoparticles, thereby achieving increased bioavailability and stability. The application of nanotechnology for the delivery of tea polyphenols would serve as a promising tool in the field of medicine. © 2016 Elsevier B.V.

Studies in Natural Products Chemistry

Nanotechnology-Based Approach for Enhanced Bioavailability and Stability of Tea Polyphenols—A Review

Food Chemistry

Influence of encapsulated functional lipids on crystal structure and chemical stability in solid lipid nanoparticles: Towards bioactive-based design of delivery systems

Colloids and Surfaces B: Biointerfaces

Galactose engineered solid lipid nanoparticles for targeted delivery of doxorubicin

European Journal of Lipid Science and Technology

Development of novel composite antioxidant multiple lipid particles from combination of W/O/W multiple emulsions and solid lipid nanoparticles

International Journal of Pharmaceutics

Resveratrol nanoformulations: Challenges and opportunities

Oxidative Medicine and Cellular Longevity

Epigallocatechin-3-Gallate Enhances the Therapeutic Effects of Leptomycin B on Human Lung Cancer A549 Cells

Positive regulation of biochemical parameters by tea polyphenol encapsulated solid lipid nanoparticles at in vitro and in vivo conditions

Journal	IET Nanobiotechnology
Publisher	Institution of Engineering and Technology (IET)
ISSN	1751-8741
Open Access	0