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Potential Anti-Inflammatory and AntiProliferative Agents and-1H-Isochromen-1-ones and their Thio Analogues and their QSAR Studies
, Sivakumar P.M, Doble M, Manivel P, Jeong E.D.
Published in Apple Academic Press
Pages: 385 - 397
A series of 1H-isochromen-1-ones and their thio analogues (1H-isochromen-1-thione) has been considered for evaluation of their cytotoxic effect on the H460 cancer cells by a propidium iodide assay. A quantitative structure-activity relationship has been developed between the cytotoxicity against H460 (at 0.1 μM) and the structural features of the compounds. Statistical measures such as r2 (0.86), q2 (0.58), pred-r2 (0.94), and F-ratio (15.22) were found to be in an acceptable range. © 2016 by Apple Academic Press, Inc.
About the journal
JournalChemometrics Applications and Research
PublisherApple Academic Press
Open Access0