This paper presents an ultralow power and area efficient TFET-based opamp for portable and wearable IoT devices in smart health monitoring and recording applications. The two-stage operational amplifier is designed with 20, nm Tunnel Field Effect Transistor (TFET). The unique features of TFET transistor would helpful to meet requirements in analog circuit designs where more demand in the area and low-voltage operation. This work shows better improvement in area and power consumption. Area optimized with an absence of miller capacitance (CMiller) is the novelty of this opamp design as compared to conventional. The Opamp is designed and simulation carried for 1–10, kHz bandwidth in Cadence environment. The simulation results show a gain of 46, dB, Phase is 68º and power consumption is 1.5 µ W with a supply of 0.5, V. © Springer Nature Singapore Pte Ltd. 2018.