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Journal Article
Predicting Therapeutic Template by Evaluating the Structural Stability of Anti-Cancer Peptides—A Computational ApproachPublished in Springer Science and Business Media LLC
2011
Volume: 17
Issue: 1
Pages: 31 - 38
Clinically significant antibiotic resistance has evolved against virtually every antibiotic deployed. Yet the development of new classes of antibiotics has lagged far behind our growing need for such drugs. Antimicrobial peptides (AMPs) have emerged as novel therapeutics hailed for their bactericidal and immunomodulatory properties. However, the process of optimizing antimicrobial peptide stability, using large peptide libraries is both tedious and expensive. The intent of this study is to analyze computationally the stability of anti-cancer peptides (ACPs) and to discover a potential template from a pool of ACPs for therapeutic use. Consequently we highlighted that ACP, NK-Lysin appears advantageous over the other ACPs with respect to stability, and may provide a convenient platform for the development of anticancer therapeutic peptide. © 2011 Springer Science+Business Media, LLC.
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About the journal
| Journal | Data powered by TypesetInternational Journal of Peptide Research and Therapeutics |
|---|---|
| Publisher | Data powered by TypesetSpringer Science and Business Media LLC |
| ISSN | 1573-3149 |
| Open Access | No |
Authors (5)
Ramanathan K- Exploring the Role of C–H….π Interactions on the Structural Stability of Single Chain “All-Alpha” Proteins
- Extraction of Bioactive Compounds from Millingtonia hortensis for the Treatment of Dapsone Resistance in Leprosy
- Identification of Novel Hepatitis C Virus NS3-4A Protease Inhibitors by Virtual Screening Approach
Prediction of Functional Loss of Human TWIK-Related Spinal Cord K+ Gene Associated with Migraine Disease Using Nanoseconds Simulation Study
Shanthi V- Exploring the Role of C–H….π Interactions on the Structural Stability of Single Chain “All-Alpha” Proteins
- Extraction of Bioactive Compounds from Millingtonia hortensis for the Treatment of Dapsone Resistance in Leprosy
- Identification of Novel Hepatitis C Virus NS3-4A Protease Inhibitors by Virtual Screening Approach
Prediction of Functional Loss of Human TWIK-Related Spinal Cord K+ Gene Associated with Migraine Disease Using Nanoseconds Simulation Study
Rajasekaran R- User authentication: Keystroke dynamics with soft biometric features
- Enhancement of Task Performance Aided by Music
- In Silico Analysis of Detrimental Missense Mutations in p110α That Cause Cancer
- Molecular Mechanics Approach of Leukodystrophy Causing E285A Mutation in Aspartoacylase Directs the Future Implementation of Nanomechanics
Sudandira Doss C- In silico investigations on functional and haplotype tag SNPs associated with congenital long QT syndromes (LQTSs)
- A novel computational and structural analysis of nsSNPs in CFTR gene
- Computational and Structural Investigation of Deleterious Functional SNPs in Breast Cancer BRCA2 Gene
- Exploring the structural constraints at cleavage site of mucin 1 isoform through molecular dynamics simulation
George Priya Doss C- Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?
- In Silico profiling of deleterious amino acid substitutions of potential pathological importance in haemophlia A and haemophlia B
- In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach
- Genetic Epidemiology of Glucose-6-Phosphate Dehydrogenase Deficiency in the Arab World
