In this paper, a prediction of diabetes disease for people of various age groups and genders is implemented using cost optimization and control chart. Generally, Diabetes is one of the metabolic diseases caused due to increase in the sugar levels of blood over a prolonged period. Diabetes will be confirmed by examining albumin and bilirubin levels and protein content in blood. This paper discusses on predicting diabetes disease among various persons and existence of disease among them using Cost optimization method. © 2017 IEEE.