This study attempts to investigate the real-time prediction of a heavy rainfall event over the Chennai Metropolitan City, Tamil Nadu, India that occurred on 01 December 2015 using Advanced Research Weather Research and Forecasting (WRF-ARW) model. The study evaluates the impact of six microphysical (Lin, WSM6, Goddard, Thompson, Morrison and WDM6) parameterization schemes of the model on prediction of heavy rainfall event. In addition, model sensitivity has also been evaluated with six Planetary Boundary Layer (PBL) and two Land Surface Model (LSM) schemes. Model forecast was carried out using nested domain and the impact of model horizontal grid resolutions were assessed at 9 km, 6 km and 3 km. Analysis of the synoptic features using National Center for Environmental Prediction Global Forecast System (NCEP-GFS) analysis data revealed strong upper-level divergence and high moisture content at lower level were favorable for the occurrence of heavy rainfall event over the northeast coast of Tamil Nadu. The study signified that forecasted rainfall was more sensitive to the microphysics and PBL schemes compared to the LSM schemes. The model provided better forecast of the heavy rainfall event using the logical combination of Goddard microphysics, YSU PBL and Noah LSM schemes, and it was mostly attributed to timely initiation and development of the convective system. The forecast with different horizontal resolutions using cumulus parameterization indicated that the rainfall prediction was not well represented at 9 km and 6 km. The forecast with 3 km horizontal resolution provided better prediction in terms of timely initiation and development of the event. The study highlights that forecast of heavy rainfall events using a high-resolution mesoscale model with suitable representations of physical parameterization schemes are useful for disaster management and planning to minimize the potential loss of life and property. © 2017 Elsevier B.V.