The present study is to compare the multiple regression analysis (MRA) model and artificial neural network (ANN) model designed to predict the mechanical strength of fiber-reinforced concrete on 28 days. The model uses the data from early literatures; the data consist of tensile strength of fiber, percentage of fiber, water/cement ratio, cross-sectional area of test specimen, Young’s modulus of fiber, and mechanical strength of control specimen, and these were used as the input parameters; the respective strength attained was used as the target parameter. The models are created and are used to predict compressive, split tensile, and flexural strength of fiber admixed concrete. These models are evaluated through the statistical test such as coefficient of determination (R2) and root mean squared error (RMSE). The results show that these parameters produce a valid model through both MRA and ANN, and this model gives more precise prediction for the fiber admixed concrete.