<h3>Objective</h3><p>To investigate the phytochemical, antibacterial, antifungal and anticandidal activity of successive extracts of <i>Crossandra infundibuliformis</i> (Acanthaceae) leaves.</p><h3>Methods</h3><p>Preliminary screening on the presence of alkaloids, saponins, phytosterols, phenolic compounds, flavanoids, tannins, carbohydrates, terpenoids, oils and fats were carried out by phytochemical analysis. The antibacterial, antifungal and anticandidal activities were done by agar well diffusion technique.</p><h3>Results</h3><p>The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0 μg/mL. In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250 μg/mL.</p><h3>Conclusions</h3><p>These findings demonstrate that the leaf extracts of <i>C. infundibuliformis</i> presents excellent antimicrobial activities and thus have great potential as a source for natural health care products.</p>

Madhumitha G

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Mary Saral A

Fulltext

<p>Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.</p>

<p>VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;<strong>VIT</strong>, Vellore as an&nbsp;<strong>Institution of Eminence</strong>. This has allowed VIT to take independent quality initiatives and move up in world ranking.</p>

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Preliminary phytochemical analysis,antibacterial,antifungal and anticandidal activities of successive extracts of Crossandra infundibuliformis

Asian Pacific Journal of Tropical Medicine

Plants are the main source of medicine which is used in traditional as well as modern medicine in recent years for curing many diseases. Carissa edulis Vahl is one of the traditional plants which have healing property on diarrhea, toothache and chest pain. The present work aims on phytochemical, antioxidant and in vitro cytotoxicity test of C. edulis dried fruits. The different solvent extracts obtained from petroleum ether, ethyl acetate, chloroform, ethanol and water have been evaluated the presence of phytochemicals. Several assays were carried out like total antioxidant, DPPH, reducing power and thiobarbituric acid to investigate the free radical scavenging property. In addition, the cytotoxicity study also carried out on human lung cancer cells (A549). Among different solvent extract, ethanol exhibited strong antioxidant activity. Additionally, the in vitro cytotoxicity test of C. edulis on human lung cancer cell (A549) showed IC50 value 405.704 ± 2.42 $\mu$g/mL. Therefore, C. edulis could be useful as a potential preventive intervention for free radicals mediated diseases as well as an antioxidant drug in the pharmaceutical industry.

IOP Conference Series: Materials Science and Engineering

Preliminary phytochemical analysis, Antioxidant and cytotoxicity test ofCarissa edulisVahl dried fruits

A facile phyto chemical extracellular synthesis of Palladium nanoparticles (Pd NPs) with the help of starting material Palladium acetate and easily available wild plant Catunaregum spinosa (C. Spinosa) were developed. The phyto chemicals present in the plant acts as secondary metabolites for Pd NPs formation. In most of the industries carcinogenic dyes are released into water bodies in an uncontrolled manner among this Congo red is also released; which said to be a toxic diazo dye. These effluents can play a prominent role in affecting the flora and fauna. In this perspective Pd NPs is synthesized by using C. spinosa root bark aqueous extract in an ecofriendly manner by using bottom-up approach. Further the Pd NPs was monitored by UV–Vis spec and characterized by FT-IR, XRD, TEM, EDAX, Zeta potential. Green synthesized Pd nanomaterials identified as agglomerated spherical shape particles and size average of 47 ± 2 nm by microscopical analysis. Further the synthesized Pd NPs were investigated against the homogenous catalytic degradation Congo red results in 83%. © 2016, Springer Science+Business Media New York.

Journal of Cluster Science

Environmental Friendly Synthesis of Palladium Nanoparticles and its Photocatalytic Activity Against Diazo Dye to Sustain the Natural Source

Ecofriendly synthesis of Palladium nanoparticles (PdNPs) were achieved using Phyllanthus emblica (P. emblica) seeds as reducing agent. Further the ecofriendly synthesized PdNPs were subjected for various analytical techniques like UV–Vis, FT-IR, XRD, Zeta potential, SEM and TEM. The results indicated that green synthesized PdNPs were spherical in shape with average particle size of 28 ± 2 nm with moderate stability. Further the synthesized PdNPs and extract were subjected for its antibacterial studies against various disease causing pathogens by agar well diffusion method. Seed extract resulted in 8.9 ± 1.46 mm against B. subtilis and PdNPs showed 9.6 ± 1.10 mm against S. aureus and synthesized PdNPs and extract were tested for hemolytic which resulted in 20% and 10% respectively. Toxicity studies were done against Artemia salina (A. salina). The LC50 value of green synthesized P. emblica capped PdNPs and the P. emblica seed extract were found to be less toxic for A. salina with a value of 1.00 μg/mL and 1.25 μg/mL. In addition samples were checked for in vitro cytotoxicity assays on HeLa cell lines. © 2016 Elsevier B.V.

Journal of Photochemistry and Photobiology B: Biology

Phyllanthus emblica seed extract mediated synthesis of PdNPs against antibacterial, heamolytic and cytotoxic studies

Dihydroquinazolinones is an important core structure reported with a wide variety of pharmacological activities. They are capable of undergoing various transformations because of its reactivity towards various reagents. The synthetic strategies for the functionalization and derivatization of the nucleus were explained. The diversified pharmacological actions of this moiety were illustrated through various biochemical pathways. The structural-activity relationship study of dihydroquinazolinones anticipated the relationship between the various substituents and its role in the pharmacological action. The main objective of this review is to summarize the importance of dihydroquinazolinones in the field of chemical biology.

European Journal of Medicinal Chemistry

Synthetic strategy with representation on mechanistic pathway for the therapeutic applications of dihydroquinazolinones

A new series of brominated derivatives of 2, 3-dihydroquinazolin-4(1H)-one were synthesized and their structures were confirmed using IR, NMR and mass spectra. The synthesized derivatives were screened for their in vitro anthelmintic activity. The investigations on interaction of the bioactive compound, 2i with bovine serum albumin (BSA) were evaluated. The quenching mechanism of the compound, 2i was deduced based on the results of Stern–Volmer equation. The number of binding site, prediction of binding site region and the changes in the secondary structure of protein were predicted using various spectroscopic studies.

Journal of Luminescence

Study of binding interaction between anthelmintic 2, 3-dihydroquinazolin-4-ones with bovine serum albumin by spectroscopic methods

Preliminary phytochemical analysis, antibacterial, antifungal and anticandidal activities of successive extracts of Crossandra infundibuliformis

<p>Objective: To analyze the hepatoprotective effect of the Crossandra infundibuliformis. Methods: Hepatotoxicity was induced by carbon tetrachloride. Petroleum ether extract of dried leaves was administrated to mice for 7 days. The hepatoprotective effect of petroleum ether extract was evaluated by the assay of liver function biochemical parameters. Results: The result clearly indicates that petroleum ether extract showed significant hepatoprotection when compared with standard Silumarin. Conclusions: The petroleum ether extract of the leaves of Crossandra infundibuliformis possess significant acute hepatoprotective activity. Thus further investigation on this species would bring a promising drug for liver disorders. © 2010 Hainan Medical College.</p>

Journal	Asian Pacific Journal of Tropical Medicine
Publisher	Medknow
ISSN	1995-7645
Open Access	Yes