Plants are the main source of medicine which is used in traditional as well as modern medicine in recent years for curing many diseases. Carissa edulis Vahl is one of the traditional plants which have healing property on diarrhea, toothache and chest pain. The present work aims on phytochemical, antioxidant and in vitro cytotoxicity test of C. edulis dried fruits. The different solvent extracts obtained from petroleum ether, ethyl acetate, chloroform, ethanol and water have been evaluated the presence of phytochemicals. Several assays were carried out like total antioxidant, DPPH, reducing power and thiobarbituric acid to investigate the free radical scavenging property. In addition, the cytotoxicity study also carried out on human lung cancer cells (A549). Among different solvent extract, ethanol exhibited strong antioxidant activity. Additionally, the in vitro cytotoxicity test of C. edulis on human lung cancer cell (A549) showed IC50 value 405.704 ± 2.42 $\mu$g/mL. Therefore, C. edulis could be useful as a potential preventive intervention for free radicals mediated diseases as well as an antioxidant drug in the pharmaceutical industry.

Madhumitha G

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Fowsiya J

Fulltext

<p>Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.</p>

<p>VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;<strong>VIT</strong>, Vellore as an&nbsp;<strong>Institution of Eminence</strong>. This has allowed VIT to take independent quality initiatives and move up in world ranking.</p>

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Preliminary phytochemical analysis, Antioxidant and cytotoxicity test of Carissa edulis Vahl dried fruits

IOP Conference Series: Materials Science and Engineering

Food science is said to be one of the vast developing fields all over the world. This chapter completely deals about the brief introduction of food science, its origin, evaluation, storage techniques, packaging, etc., This food science can be evolved from different types of sources, like plants and animals which plays a major role in day today life. This chapter also comprises of important components present in the food science such as carbohydrates, proteins, vitamins, fats, oils, etc., and also this chapter deals about the importance of food technology in various applicational studies, for example, nanobiotechnology, agricultural fields, etc., overall this chapter comprises of importance about food science and its regulation which will facilitate the upcoming researchers to focus on food science. © Springer International Publishing AG, part of Springer Nature 2018.

Bioorganic Phase in Natural Food: An Overview

An Introduction and Overview of Food Science on Day Today Life

Present and future health care systems are more demanding on the discovery and usage of novel drugs, which should have a potent target system with the pharmacokinetic and pharmacodynamic properties. Available drugs used currently are chemically synthesized and some of them are yet to be studied for their toxicity assessment. Bioorganic phase can be an indispensable field on isolating and identifying the metabolites from the food sources has become trend in recent days. Indian food systems are embedded with the Indian system of medicine. Indian food plants and Indian spices are highly enriched with the medicinal properties. Their applications are vital in industrial and pharmaceuticals. Hence, isolation of the novel compounds is one of the goal in bioorganic phase by various methods, it may be either traditional (decoction, maceration and solvent extraction) or by recent (ultra-sonication, microwave assisted and enzymatic extraction) methods. Identification and characterization of compounds can be done through chromatographic techniques and spectroscopic methods. This chapter deliberates with phyto-constituents from the common food plant products such as vegetables, spices and condiments. Their important phyto-compounds having pharmacological actions and how they were isolated, identified and characterized using different methods were discussed. This could help in gaining knowledge on the important compounds and their properties present in food products. © Springer International Publishing AG, part of Springer Nature 2018.

Isolation and Characterization of Bioorganic Phase from Food Source

This book chapter scrutinizes the total synthesis of natural products extricate from fruits and vegetables and its biological activities allied to certain diseases. Generally, natural products are extricated from plants and their products. Which render nutrition, phytochemicals, vitamins, fibers, and minerals etc.., these are manifest numerous biological activities such as antioxidant, antibacterial, anti-inflammatory, and antifungal activity etc., hostile to chronic diseases like cancer, Alzheimer's, heart disease, arthritis, and asthma etc., at a certain level, and gift with good health. Natural products are present in the free form or associated with glycosides in little quantity, sometimes difficult to isolated in pure form. Therefore, total synthesis plays a major role in the current engrossment, synthesis and its study allied to biological activities. © Springer International Publishing AG, part of Springer Nature 2018.

Total Synthesis of Natural Products Existence in Fruits and Vegetables

Controlling of Food Borne Pathogens by Nanoparticles

The practice of treating various disease using medicinal plants are as older as an ancient civilization. Secondary metabolites present in the plants are predominantly responsible for treating various ailments. Secondary metabolites are also called as plant constituents or natural compounds which exert significant pharmacological and toxicological effects in humankind. The chemical compounds present in the plant sources are categorized as primary and secondary metabolites based on the chemical structure and biosynthetic derivation. Secondary metabolites exhibit different series of pharmacological activity which can be further classified based on their chemical structure and functional groups present in it. The most important secondary metabolites include terpenoids, phenolics, flavonoids, alkaloids and glycosides which act as an important source for single bioactive ingredients in nutraceuticals and modern medicines. Secondary metabolites have a very good antioxidant property which can be used as an effective natural antioxidants source in nutraceuticals. Most of the secondary metabolites have a broad range of their therapeutic activity and they directly interact with the receptors, cell membranes, and nucleic acids. This review evaluates the meticulous report of secondary metabolites, their classification, phytochemistry, pharmacological activity and its application in modern medicines which may pave the way for knowledge to identify and isolate the desired pharmacologically active lead compound in the drug discovery. © Springer International Publishing AG, part of Springer Nature 2018.

Phytochemical and Pharmacological Importance of Plant Secondary Metabolites in Modern Medicine

Preliminary phytochemical analysis, Antioxidant and cytotoxicity test ofCarissa edulisVahl dried fruits

Inflammation plays an important role in various diseases with high prevalence within populations such as rheumatoid arthritis, ulcer, atherosclerosis, and asthma. Many drugs are available in the market for inflammatory diseases. They exhibit several unwanted side effects to humans. Therefore, alternative treatments with safer compounds are needed.Carissa carandasplant is used in traditional medicinal system for its various diseases curing property. In the present study, we examined the anti-inflammatory effects of dried fruit methanol extract on carrageenan-induced hind paw edema in rats.C. carandaswas defatted with petroleum ether, followed by methanol extraction. The methanol extracts of the dried fruits ofCarissa carandaswere given orally to the experimental rats caused significant activity (P≤0.05) when compared with the control group. The maximum inhibition of paw edema was found to be in Group V, that is, 76.12% with inhibition of paw volume in a dose-dependent manner. The anti-inflammatory activity of the methanol extract of the dried fruits shows that the presence of potential constituents present in this extract may provide assistance in the drug discovery process. The phytochemical compounds of the extract were screened by GC-MS analysis and it was found that 11 compounds are present in methanol extract of dried fruits ofCarissa carandas.

BioMed Research International

Role of Dried Fruits ofCarissa carandasas Anti-Inflammatory Agents and the Analysis of Phytochemical Constituents by GC-MS

<h3>Objective</h3><p>To investigate the phytochemical, antibacterial, antifungal and anticandidal activity of successive extracts of <i>Crossandra infundibuliformis</i> (Acanthaceae) leaves.</p><h3>Methods</h3><p>Preliminary screening on the presence of alkaloids, saponins, phytosterols, phenolic compounds, flavanoids, tannins, carbohydrates, terpenoids, oils and fats were carried out by phytochemical analysis. The antibacterial, antifungal and anticandidal activities were done by agar well diffusion technique.</p><h3>Results</h3><p>The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0 μg/mL. In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250 μg/mL.</p><h3>Conclusions</h3><p>These findings demonstrate that the leaf extracts of <i>C. infundibuliformis</i> presents excellent antimicrobial activities and thus have great potential as a source for natural health care products.</p>

Journal	Data powered by TypesetIOP Conference Series: Materials Science and Engineering
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ISSN	1757-8981
Open Access	Yes