In wireless networks, spoofing attack is one of the most common and challenging attacks. Due to these attacks the overall network performance would be degraded. In this paper, a medoid based clustering approach has been proposed to detect a multiple spoofing attacks in wireless networks. In addition, a Enhanced Partitioning Around Medoid (EPAM) with average silhouette has been integrated with the clustering mechanism to detect a multiple spoofing attacks with a higher accuracy rate. Based on the proposed method, the received signal strength based clustering approach has been adopted for medoid clustering for detection of attacks. In order to prevent the multiple spoofing attacks, dynamic MAC address allocation scheme using MD5 hashing technique is implemented. The experimental results shows, the proposed method can detect spoofing attacks with high accuracy rate and prevent the attacks. Thus the overall network performance is improved with high accuracy rate. © 2014 IEEE.