Inflammation is the root cause of many diseases. Chronic inflammation in the gut leads to many inflammatory diseases, primarily due to dysbiosis. Evolution of the gut among mammals is host to a large number of microbiota and it appears their number and quantity are quite significant in maintaining the physiological equilibrium, for homeostasis in general and especially the gut, in particular The evolutionary symbiosis between host and allochthonous microbiota can restore peace and balance in a system overcoming immunological intolerance. This is important to understanding the cause of balance in the gut. Specific probiotic characteristics of microbiota are required to maintain homeostasis. The inflammation of the gut may start from a mere infection, antibiotic use/abuse, dysbiosis, or the upregulation of proinflammatory molecules that comes with aging. Probiotics offer great potential to support gut health and regulate the causes of inflammation. The active surface components, the secondary metabolites, or/and biohydrogenation capabilities of probiotics in the gut reduce or remove the causes of inflammation, and thus relieve the host. © 2018 Elsevier Inc. All rights reserved.