In this study, Mangifera Indica (mango) seed kernel powder was used as an adsorbent for chromium(VI) removal. The interactive effects between the process variables such as pH, temperature, adsorbent concentration, chromium concentration, and stirring speed (RPM) on chromium(VI) removal have been studied. In order to optimize the process, the experiments were designed using central composite design under response surface methodology by MINITAB 16.0 software. Based on the study, the optimum conditions for maximum removal of chromium(VI) from synthetic solution were obtained as: pH 1, temperature 27.5°C, adsorbent concentration 3.5 g/L, chromium concentration 100 ppm, and RPM 75. The statistical analysis of the data shows that experiments are statistically significant with a regression coefficient (R2) value of 0.95. © 2013 Balaban Desalination Publications. All rights reserved.