Objective: The present investigation was carried out to assess the protective properties of Spirulina fusiformis against galactosamine induced toxicity in swiss albino mice. Methods: Evaluation of serum glutamate oxaloacetate transferase (SGOT), serum glutamate pyruvate transferase (SGPT), alkaline phosphatase (ALP), serum bilirubin (SBLN), antioxidant status and TNF-α was done and was compared with the standard reference drug silymarin. Results: Galactosamine injection significantly increased the levels of SGOT, SGPT, SBLN and TNF-α in the serum and caused depletion in the antioxidant status in the liver. Administration of Spirulina fusiformis altered these parameters and brought them near to normal levels. Conclusion: Hence results of this study clearly indicate that Spirulina fusiformis has hepatoprotective activity against galactosamine induced toxicity in mice.