The ethyl-2-chloroquinoline-3-carboxylates, 4, were achieved fromo-aminobenzophenones in two steps. i.e. initially, the ethyl-2-oxoquinoline- 3-carboxylates, 3, were obtained by base-catalyzed Friedlander condensations of o-aminobenzophenones, 1, and diethylmalonate, 2. The 2-chloroquinoline-3- carboxylates, 4, were then obtained by the reaction with POCl3 in good yields. The chemical structures were confirmed by FTIR, mass and 1H-NMR spectroscopic techniques. All the synthesized compounds were tested for their in vitro antibacterial activity against Bacillus subtilis and Vibrio cholera and found to possess moderate activity. © Springer Science+Business Media B.V. 2012.

Krishnakumar K

Department of Multimedia

School of Design

Vellore Campus

Nawaz Khan F

Department of Chemistry

School of Advanced Sciences

Badal Kumar Mandal

Mitta S

Dhasamandha R

Govindan V.N.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Research on Chemical Intermediates

A simple, efficient and rapid method for clay-catalyzed Knoevenagel condensation of heterocyclic aldehydes with active methylene compound under reflux condition is reported. This protocol offers high yield, shorter time and simple work procedure. The protocol does not require column chromatography for purification, and the process is environmentally benign. © 2014 Springer Science+Business Media.

Montmorillonite-KSF-catalyzed synthesis of 4-heteroarylidene-N-arylhomophthalimides by Knoevenagel condensation

A series of indazol-2-yl(pyridin-4-yl)methanones, 4 were acquired from 2,6-bisbenzylidene cyclohexanones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs (streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL). © 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Chinese Chemical Letters

Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

Tetrahydroacridine-1,8-(2H,5H,9H,10H)-diones 4 from 1,3-cyclohexanedione and/or dimedone 1,2-chloro-3-formylquinoline 2 and anilines 3 in water at 90 °C were obtained by domino reaction approach.

RSC Advances

Water mediated reactions: TiO2 and ZnO nanoparticle catalyzed multi component domino reaction in the synthesis of tetrahydroacridinediones, acridindiones, xanthenones and xanthenes

Quinoline-3-carboxylates as potential antibacterial agents

An efficient and facile one-pot synthesis of 1,3-disubstituted isoquinolines 3 was accomplished from 3-substituted isocoumarins 1 through diketones, formed in situ via the Grignard reaction, in the presence of ammonium acetate, montmorillonite K-10 catalyst, and ethanol solvent. © Springer Science+Business Media B.V. 2011.

Facile benzannulation of isocoumarins in the efficient synthesis of diversified 1,3-disubstituted isoquinolines

Synthetic Communications

Synthesis of Some 3‐Substituted Isochromen‐1‐ones

ChemInform

ChemInform Abstract: Synthesis and Anticancer Properties of Pyrimido(4,5-b)quinolines.

Bioorganic & Medicinal Chemistry

Synthesis and evaluation of a novel series of quinoline derivatives with immunosuppressive activity

Journal	Data powered by TypesetResearch on Chemical Intermediates
Publisher	Data powered by TypesetSpringer Science and Business Media LLC
ISSN	0922-6168
Open Access	0