Magnetohydrodynamics (MHD) three-dimensional flow of an unsteady Williamson fluid on an enlarging surface with Hall current, radiation, heat source/sink, and chemical reaction is investigated in this article. The basic governing equations are transformed into a system of ordinary differential equations by using an appropriate similarity transformation. The system is deciphered using the shooting method. The properties of influential parameters such as parameters of magnetic field, Hall current, radiation, and so forth, on the flow are discussed with the help of graphs and tables. We noticed that the increase in the magnetic field reduces the velocity in x-direction and the rate of heat and mass transfer. We also acknowledged that the growing values of Hall current parameter boost the velocity in z-direction but it reduce the temperature and concentration distributions, respectively. The results of this study represent many applications in biomedical engineering and these results are helpful for further study of non-Newtonian fluids in various circumstances. © 2020 Wiley Periodicals LLC