Manimaran S.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Radiation Medicine

Background: The linear quadratic model has led to various methods for the calculation of isoeffect relationships in radiotherapy. In this model, the tissue sensitive parameters α and β usually appear as a ratio, α/β. These parameters are used to describe the response of normal tissues to radiation insult. Different radiation induced biological end points in specific tissues and organs are associated with the characteristics of the α/β ratio. The linear quadratic model has been used clinically to address questions relating to changes in fractions in treatment schedules. Aim: The process of treating cancer with ionizing radiation is complex and subject to dosimetric errors which may potentially result in early or late complications. Our objective was to correct such errors through the application of the incomplete repair linear quadratic model. Materials/Methods: Repair mechanisms are affected if, owing to dosimetric error, excess dose is delivered in single or multiple fractions. Corrections for such errors were simulated, for different clinical situations, in order to avoid late fibrosis in head and neck cancers. Results: NSD, CRE, and TDF approach could not predict, onset of proliferation, overall treatment time, late and early complications, but linear quadratic model calculations predicts isoeffective schedules successfully with above parameters. Conclusions: In head and neck cancers, a number of parameters influence the results of treatment. Isoeffect calculations show the risk factors responsible for fibrosis and spinal cord damage and therefore may be used to calculate dose reductions for all remaining fractions, rather than applying shielding.

Reports of Practical Oncology & Radiotherapy

Isoeffect calculations based on linear quadratic equations for head and neck cancers

Acta Oncologica

Mathematical Models of Tumour and Normal Tissue Response

The British Journal of Radiology

The clinical radiobiology of brachytherapy.

Radiotherapy and Oncology

The effect of tumour shrinkage on biologically effective dose, and possible implications for fractionated high dose rate brachytherapy

International Journal of Radiation Oncology*Biology*Physics

High dose rate intracavitary brachytherapy for carcinoma of the cervix: The madison system: I. Clinical and radiobiological considerations

Radiobiological equivalent of low/high dose rate brachytherapy and evaluation of tumor and normal responses to the dose

Journal	Data powered by TypesetRadiation Medicine
Publisher	Data powered by TypesetSpringer Science and Business Media LLC
ISSN	0288-2043
Open Access	0