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Regioselective synthesis of 3,4,6,7-tetrahydro-3,3-dimethyl-9-phenyl-2H-xanthene-1,8(5H,9H)-diones through ascorbic acid catalyzed three-component domino reaction
, , Jeong E.D, Chung E.H.
Published in Elsevier BV
Volume: 55
Issue: 41
Pages: 5656 - 5659
An efficient, three-component domino reaction of dimedone 1, aromatic aldehydes (2a-o), and 1,3-cyclohexanedione 1a in the regio-selective synthesis of 3,3-dimethyl-9-phenyl-2H-xanthene-1,8(5H,9H)-diones (3a-o) is reported. The desired product, 3 is efficiently promoted by ascorbic acid as an organo catalyst. © 2014 Elsevier Ltd. All rights reserved.
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JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier BV
Open Access0