In this article, we determine a set of appropriate conditions for approximate controllability of second-order Sobolev-type impulsive neutral differential evolution inclusions with infinite delay. We verify the main results by applying ideas about the cosine function, sine functions, and fixed point approach. Next, we continue the discussion to the nonlocal second-order Sobolev-type differential system. In the end, we provide a theoretical application to assist in the effectiveness of our discussion. © 2020 Wiley Periodicals LLC