Effects of administration of sodium fluoride and aluminium chloride at doses of 10 mg and 200 mg/kg body weight, respectively, were studied for 30 days on the liver and muscle of female mice (Mus musculus). The possible therapeutic effects of vitamin C (AA, 15 mg/animal/day), Ca (25 mg/animal/day) or vitamin E (2 mg/animal/day) administered alone or in combination on NaF+AlCl3-treated animals during the withdrawal period were also investigated. A decrease in the protein levels of liver and gastrocnemius muscle by F and Al might be due to alteration in metabolism. A significant accumulation of glycogen levels in liver and muscle could be correlated with reduced activity of phosphorylase. Hence carbohydrate metabolism was altered in these organs. The decline in the activity of SDH in the gastrocnemius muscle and liver suggests reduction in their oxidative metabolism which could be related to structural alterations in the mitochondria. A decrease in activity of cholinesterase in liver and muscle may result from toxic effects of NaF, AlCl3, and NaF+AlCl3, which might have led to alteration in the utilization of acetylcholine thus affecting the transmission of nerve impulses in these tissues. Elevated levels of SGPT and SGOT may indicate hepatic damage and changes in its function by the treatments. Upon withdrawal of combined treatment, a significant recovery occurred in most of the parameters of liver, muscle and serum. However, none of the values were comparable to control. On the other hand, cholinesterase activity in liver and muscle as well as phosphorylase in liver recovered partially. The toxic effects of NaF+AlCl3 on all the parameters were reversed significantly by the administration of AA, Ca, or vitamin E alone, probably due to the antioxidant action of AA and vitamin E and the role of calcium in metabolism. By the combined treatment with these antidotes, complete recovery occurred and values were comparable to control in all the parameters studied which might be the result of their additive or synergistic effect.