The aim of this study is to investigate the larvicidal activity of crude extracts obtained from petroleum ether (A), ethyl acetate (B) and methanol (C) of C. infundibuliformis against Anopheles Stephensi, Aedes aegypti and Culex quinquefasciatus. Six fourth-instar mosquito larvae were used for the study. The experimental results demonstrated that, petroleum ether extract (A) have significantly reduced the mortality of the larvae when compared with other two extracts. The results showed that the extracts of C. infundibuliformis may be considered as a potent source for new drug. The bioactivity-guided fractionation, isolation and identification will bring out potential drug to mankind, especially with anti-infective properties.