Global warming is one of the major consequences of anthropogenic and industrialization activities, which have caused a substantial increase in the concentration of CO2 in the atmosphere. This increase in CO2 concentration has caused measurable global warming and created adverse effects on the ecosystem. This could be resolved by using several technologies - such as chemical catalysis, along with photochemical, electrochemical, biological, bioelectrochemical, and inorganic transformation technologies - by utilizing CO2 for the production of fuels and value-added products. This chapter discusses the different biological systems, such as photosynthesis, bioelectrosynthesis, and gas fermentation, for CO2 sequestration. The study also discusses the mechanisms involved in the photosynthesis processes and their metabolic pathways, which regulate the CO2 in value-added products. Bioelectrosynthesis uses the inorganic compounds through a series of microbially or enzymatically catalyzed reactions in a fuel cell setup for the production of fuels and chemicals by applying external potential. Gas fermentation is an up-and-coming technology, which uses syngas as a substrate by enriching the microorganisms in a moderate temperature and low pressure for the production of low-carbon fuels and synthesis of commodity chemicals. © 2019 American Chemical Society.