Cloud computing is an emerging technology that is expected to support internet-scale critical applications, which could be essential to the healthcare sector. Its scalability, resilience, adaptability, connectivity, cost reduction, and high-performance features have high potential to lift the efficiency and quality of healthcare. With the widespread application of healthcare information and communication technology, constructing a stable and sustainable data sharing circumstance has attracted rapidly growing attention in both academic research area and the healthcare industry. Cloud computing is one of long dreamed visions of healthcare cloud (HC), which matches the need of healthcare workers, information sharing directly to various health providers over the internet, regardless of their location and the amount of data. This chapter proposes a cloud model for health information sharing and integration in HC and looks into the arising challenges in healthcare.