Autonomous vehicle is designed to perform all various operations synchronously to work under necessary regulations, liability, acceptance, and safety with Industrial IoT. The autonomous vehicle mainly works with three sensors, such as Camera, RADAR, and LIDAR. These sensors gather the information data like image, distance, waves and provide it to the electronic controllers, where it processes to take the appropriate actions. During the processing of the information, various parameters, such as latency, packet loss, and bandwidth, are evaluated using the historical and available information. The information data generated by the sensors are processed using various signal conditioners to meet the required parameters. In this chapter, some of the signal conditioning methods, such as RF module, BTS, TPMS, and capacitive balancing of humidity sensor (in HVAC), are used in autonomous vehicle and Industrial IoT implementation. The communication modes and their aspects from Industrial Internet of Things are discussed and existing methods for the systems are analyzed from the signal conditioning perspective. © 2021, Springer Nature Switzerland AG.