An efficient, practical, and eco-friendly method of preparation of 9-chloro-6,13-dihydro-7-phenyl-5H-indolo[ 3,2-c]-acridines (3a-c) is reported by Friedlander condensation of 2-amino-5-chlorobenzophenone 1 and active methylene compound 3,4-dihydro-2H-carbazol-1(9H)-ones (2a-c) in the presence of SnO 2 nanoparticles under microwave irradiation. Indoloacridines, 3a-c, were screened for their in vitro hemolytic activity, on human erythrocytes and cytotoxicity, on HeLa and Vero cells. © Springer Science+Business Media, LLC 2010.

Mohana Roopan S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Nawaz Khan F

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Medicinal Chemistry Research

This work describes the nitric acid catalysed synthesis of wollastonite (CaSiO3) nanoparticles (NP) from tetraethyl orthosilicate and calcium nitrate tetrahydrate. The formed calcium silicate nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), Powder X-ray Diffraction (PXRD), and scanning electron microscopy (SEM) equipped with X-ray micro analysis. The CaSiO3 NPs showed an excellent yield (93%) towards the synthesis of quinolines via Friedlander reaction. The synthesized compound 3-dimethyl-7-nitro-9-phenyl-3,4-dihydroacridin-1(2H)-one was characterized by various spectroscopic techniques. © 2017 Taylor &amp; Francis Group, LLC.

Inorganic and Nano-Metal Chemistry

Synthesis of calcium silicate nanoparticles and its catalytic application in Friedlander reaction

Zinc oxide (ZnO) nanoparticles (NPs) are important materials when making different products like sun screens, textiles, and paints. In the current study, the photocatalytic effect of prepared ZnO NPs from Moringa oleifera (M. oleifera) was evaluated on degradation of crystal violet (CV) dye, which is largely released from textile industries and is harmful to the environment. Preliminarily, ZnO NP formation was confirmed using a double beam ultraviolet visible (UV-Vis) spectrophotometer; further, the NP size was estimated using XRD analysis and the functional group analysis was determined using Fourier transform infrared (FT-IR) spectroscopy. The morphology of the synthesized NPs was found to be a hexagonal shape using SEM and TEM analysis and elemental screening was analyzed using EDX. ZnO NPs were shown sized 40–45 nm and spherical in shape. The degradation percentage of ZnO NPs was calculated as 94% at 70 min and the rate of the reaction –k = 0.0282. The synthesized ZnO NPs were determined for effectiveness on biological activities such as antifungal, hemolytic, and antibacterial activity. ZnO NPs showed good antifungal activity against Alternaria saloni and Sclerrotium rolfii strains. Further, we have determined the hemolytic and antibacterial activity of ZnO NPs and we got successive results in antibacterial and hemolytic activities. © 2016, The Author(s).

Fulltext

Nanoscale Research Letters

Vegetable Peel Waste for the Production of ZnO Nanoparticles and its Toxicological Efficiency, Antifungal, Hemolytic, and Antibacterial Activities

A conventional approach has been used to synthesis Indole fused acridine, 4a–e. In this paper to achieve the target molecule, 4 the reaction was performed via two steps. In step 1, there was a reaction between Carbazolone, 1 and benzophenone, 2 to get dihydroindoloacridine, 3. In step 2, compound, 3 was treated with 5{\%} Palladium/Carbon in the presence of diphenyl ether for 5 h to give a dark brown product, 4. The column chromatography was used to purify final product, 4. All the synthesized compounds such as 3 and 4 were characterized by melting point, FTIR, 1H NMR and Mass spectra. Further to check the purity of the compounds it was subjected to CHN analyzer. The target molecules such as 3 and 4 were screened for antimicrobial studies against bacteria such as Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), Klebsiella pneumonia (K. pneumonia), Salmonella typhi (S. typhi); and fungi like Aspergillus niger (A. niger), Aspergillus fumigatus (A. fumigatus). The obtained results clearly proves that the target molecules shown reasonable activity against K. pneumonia and A. niger. Further the compounds were screened for free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH). The free radical scavenging property was performed using UV–Visible spectroscopy. The results were compared with the standard BHT (Butylated Hydroxy Toluene). Compounds, 4a and 4e were shown higher percentage of inhibition when compare to the standard. The result confirms that further research on indoloacridine will leads effective drug to the market.

Journal of Photochemistry and Photobiology B: Biology

Application of UV–Vis spectrophotometric process for the assessment of indoloacridines as free radical scavenger

Cocos nucifera is one of the highest nutritional and medicinal value plants with various fractions of proteins which play a major role in several biological applications such as anti-microbial, anti-inflammatory, anti-diabetic, anti-neoplastic, anti-parasitic, insecticidal, and leishmanicidal activities. This review is focused on several biotechnological, biomedical aspects of various solvent extracts collected from different parts of coconut and the phytochemical constituents which are present in it. The results obtained from this source will facilitate most of the researchers to focus their work toward the process of diagnosing diseases in future. © 2016, Springer Science+Business Media New York.

Applied Biochemistry and Biotechnology

An Overview of Phytoconstituents, Biotechnological Applications, and Nutritive Aspects of Coconut (Cocos nucifera)

Bottle gourd (Lagenaria siceraria) belongs to the family Cucurbitaceae, which comprises about 118 genera and 825 species. It is an important vegetable crop of India, and its production is influenced by a number of factors viz., environmental, nutritional, cultural operation and use of plant growth regulators. Since, bottle gourd belongs to a medicinal family, it plays a major role in the treatment of several diseases related to the skin and heart. There are several organic chemical compounds including vitamin B complex, pectin, dietary soluble fibres, ascorbic acid, beta-carotene, amino acids and minerals which have been isolated from this species. Therefore, the bottle gourd is considered to have a great impact on therapeutic health benefits. Due to drastic industrialization and urbanization, most of the human beings are facing several ill effects which may lead to death at extreme cases. Hence, the major research area was said to be nanotechnology. Taking into consideration, we have combined nanotechnology field with waste source in the name of green synthesis and planned to cure several diseases, as most of the researchers focused their work on this and succeeded too. The present study is a complete review of L. siceraria that covers the ethnomedical uses, chemical constituents, and pharmacological profile. This study is mainly focused on the antibacterial, hepatoprotective, diuretic and anthelminthic activities. © 2015, Springer-Verlag Berlin Heidelberg.

Applied Microbiology and Biotechnology

Biotechnology and pharmacological evaluation of Indian vegetable crop Lagenaria siceraria: an overview

A moderately halophilic actinomycete strain was isolated from marine sediments collected at the Marakkanam coast of Tamil Nadu, India. The taxonomic position was evaluated by polyphasic approach and the strain was identified as a member of the genus Streptomyces. The strain is congruent with the description of the genus Streptomyces due to the characteristics of white aerial cell mass, spiral spore chains and a rough spore surface, menaquinones of MK-9 (H4, H2 and H6) types and belongs to cell-wall type I. The G + C content of the isolated DNA is 71.3 mol% and the 16S rRNA sequence of the strain shows a maximum of 93% similarity with Streptomyces HBUM 49447. The comparison of phenotypic data of closest strains with the isolate clearly indicates that our strain belongs to the genus Streptomyces. Based on the phenotypic and phylogenetic analysis, the strain was classified as a new species of the genus Streptomyces and designated as VITSDK1. The media and cultural conditions for maximal growth have been optimized under shake-flask conditions by measuring the dry weight of the mycelium. The maximal growth was attained with the use of optimized production medium, pH of 7.2 and incubation temperature of 27 °C. The growth of the strain was salt concentration dependent and maximal growth was attained at 15% salt concentration which indicates the halophilic nature of the isolate. Streptomyces VITSDK1 spp. exhibits significant hemolytic activity against rat erythrocytes with the EC50 value of 127 μg/ml and for human erythrocytes 168 μg/ml. Further, it shows moderate antibiosis against fungi and bacterial pathogens. © 2009 Elsevier Masson SAS. All rights reserved.

Journal de Mycologie Médicale

Hemolytic activity of Streptomyces VITSDK1 spp. isolated from marine sediments in Southern India

Solvent-free syntheses of quinazolin-4(3H)-ones were performed by reaction of anthranillic acid with different amides, such as nicotinamide, benzamide, formamide, etc., on montmorillonite K-10. Products were confirmed by FTIR, 1HNMR, and 13CNMR spectroscopic techniques. All synthesized compounds exhibited antioxidant properties and have been compared with standard antioxidant BHT.Key words: quinazolinone, montmorillonite K-10, solvent-free conditions, antioxidant properties.

Journal	Data powered by TypesetMedicinal Chemistry Research
Publisher	Data powered by TypesetSpringer Science and Business Media LLC
ISSN	1054-2523
Open Access	0