Dengue fever is a viral disease of the tropics, transmitted by mosquitoes causing sudden fever and acute pain in the joints. The statistical data on Dengue was seen in detail, with respect to its pathogenesis and epidemiology. We have also discussed the life cycle of the vector that bears the Flavivirus. Experimental drugs were listed out in this paper, which may cure this deadly disease. Also, a natural therapy, in the form of papaya leaf juice has been identified and discussed in the paper. Mutations found in the virus have been discussed, and has emphasized the need to find a cure. Computational applications towards analysing the number of Dengue cases and deaths have been found and are used to keep a check on how the disease spreads. Graphical representation on the variation of the number of cases and deaths with respect to the disease helps to understand the most vulnerable states in India towards the Dengue virus, as well as how medical care has improved over the years, bringing the number of reported cases down. The article has tried to come up with a concise detailing of Dengue infection, its mechanism, its drugs and their specific targets, its databases and the drug resistance mutations. The main facts and figures, as to which countries of the world are affected by this disease, as well as number of cases that were reported to WHO was also discussed.